For the first time, there is an approved medicine made specifically for non-cystic fibrosis bronchiectasis.
On 12 August 2025, the US Food and Drug Administration (FDA) approved Brinsupri™ (brensocatib), a once-a-day tablet developed by Insmed Incorporated.
This is a big step forward for people with bronchiectasis, who until now have had no targeted treatment for the inflammation that drives this disease.
What Is Brinsupri?
- A daily pill you take by mouth.
- Works by reducing inflammation in the airways, which can help prevent flare-ups (also called exacerbations).
- May slow down the loss of lung function over time.
- It is the first medicine approved for bronchiectasis anywhere in the world.
Why Is This Important?
Bronchiectasis is a long-term lung condition where the airways are widened and filled with mucus. This makes infections more likely and can cause:
- Chronic cough
- Shortness of breath
- Tiredness
- Frequent flare-ups that make symptoms worse
Until now, treatments have mainly been:
- Airway clearance (techniques or devices to remove mucus)
- Antibiotics for infections
- Lifestyle care (exercise, healthy eating, vaccines and no smoking)
Brinsupri is different—it targets one of the root causes of the disease: inflammation.
What Did the Research Show?
In a large global study (over 1,700 people in 35 countries):
- People taking Brinsupri had fewer flare-ups, or exacerbations, than those on a placebo (dummy pill).
- The time until their first flare-up was longer.
- Some people kept their lung function better after a year of treatment.
- Side effects were mostly mild and included cough, skin rash, dry skin and some dental issues.
When Will It Be Available?
- Brinsupri is approved in the US now.
- The company plans to apply for approval in the UK, Europe and Japan in 2025.
- If approved, it could be available here within the next 1–2 years.
Important notes for the UK:
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Brinsupri is not yet available in the UK. It would need approval from the Medicines and Healthcare products Regulatory Agency (MHRA) before it could be prescribed here.
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This is a brand-new type of therapy, so even once available, doctors will be learning more about which patients might benefit most and what kinds of improvements it can bring.
What Should I Do Now?
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- Keep following your current treatment plan: airway clearance, exercise, nutrition, sleep and staying up to date with vaccines are still essential.
- Talk to your healthcare provider at your next appointment – ask if Brinsupri might be suitable for you in the future.
- Sign up to our website and stay connected – we will share updates as soon as we know more about UK approval and access.