Tolerability testing

Our phase II studies test the treatment on a larger group of people who have interstitial lung disease or lung infection to see if it is well tolerated and safe and to see if there are early indicators that it might help the participants with these conditions.

Interstitial lung diseases

  • The CANAL Study: A phase II, double-blind, randomized, placebo-controlled, two-treatment, two-period crossover efficacy and safety study in Idiopathic Pulmonary Fibrosis with Nalbuphine ER tablets for the treatment of cough:
    • To investigate the efficacy and safety of Nalbuphine ER tablets in reducing chronic cough in patients diagnosed with IPF.  Click here for more info.  Now closed to recruitment following positive interim analysis results.
  • The AIR Study / C21 in IPF: A phase 2, multi-centre, open-label, single-arm trial investigating the safety, efficacy and pharmacokinetics of C21 in subjects with Idiopathic Pulmonary Fibrosis:
    • The purpose of this study is to treat participants with C21 twice daily for a minimum of 3 months and up to 9 months, to see if it can slow down the scarring and improve breathing. Specifically, we want to compare breathing ability before and after C21 treatment.
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COVID-19

  • COVASE Study – Investigation of an approved nebulised human Dnase enzyme (Pulmozyme) to reduce hyperinflammation in hospitalised people with COVID-19:
    • The purpose of this trial is to provide nebulised Pulmozyme that is expected to reduce the inflammation and stop COVID-19 from getting worse. Nebulised Pulmozyme has been used to treat thousands of adults and children with cystic fibrosis safely since 1994.

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